This post was updated April 2009. See the latest Five Best with Matrixyl 3000 here
One of the most frequently searched terms on Truth In Aging is matrixyl 3000. This antioxidant is made by combining two peptides, palmitoyl oligopeptide and palmitoyl tetrapepide-7. It outperforms Vitamin C (and unlike some of the Cs, it doesn’t irritate) by stimulating the matrix molecules – collagens 1,3, 4 and fibronectin to reduce the appearance of wrinkles. According to clinical trials, matrixyl 3000 led to a 33% decrease in wrinkle density, a 23% decrease in the volume of wrinkles and a 20% decrease in the depth of wrinkles.
The only problem is that this research was conducted by Sederma, the manufacturer of matrixyl 3000, and I haven’t been able to find any independent research. Still, assuming that it is a good antioxidant, it is worth rounding up Truth In Aging’s picks for the Five Best products that contain matrixyl 3000.
Bellaplex (usually $89, Bellaplex 1oz can be bought for $43 at Amazon.com
Isomers Matrixyl 3000 Rejuvenation Serum ($30). For a largely unadulterated matrixyl 3000 experience, it doesn’t get much better than this. There is glycerin and linseed oil and not much else. For the full ingredients of this and the rest of the Five Best click ‘continued reading’ at the end of the post to get to the next page. Isomers Matrixyl 3000 Rejuvenation Serum can be bought at Amazon.com
Your Best Face Correct ($150). Regular readers of Truth In Aging will know that YBF Correct is my new favorite eye cream. It has made a visible difference by eliminating some of the fine lines around my eyes. It contains matrixyl 3000, but doesn’t rely on it. The other important anti-ager in Correct is spin trap, a clever little molecule that traps free radicals and stops them spinning out of control and causing havoc with your skin cells.
Nutra-Lift Rejuvenating Therapy ($51.30). Nutra-Lift has recently changed its formula for Rejuvenating Therapy to add in matrixyl 3000 for the first time. I haven’t tried this, but based on reviewing the ingredients, I am sorely tempted to. Matrixyl 3000 is at a concentration of 5% and Nutra-Lift has also jammed in an impressive number of other good antioxidants including copper peptides, CoQ10, grape, tea and algae. There is also marine collagen. UPDATED 9/19/08 I bought this, reviewed it and like it.
Cellbone Super AOX ($72 but currently on promotion for $36 on Cellbone’s website). I have had extremely enthusiastic reports from readers claiming great results with Super AOX. This seems to be a good one for men. It has a hefty 10% dose of matrixyl 3000. Plus there is 1% CoQ10.
Notable for its absense from Five Best products with matrixyl 3000 is Dermapril SP. While there are some good things about Dermapril, it loses points for having at least 20 filler ingredients that won’t do much, if anything, for you and there is an onerous monthly payment scheme. I just don’t think Dermapril SP reprepsents good value for money.
*Note that the new version of Mychelle Supreme no longer contains matrixyl 3000 (apparently because it didn’t meet Mychelle’s standards of hygiene), so we haven’t included it here. Myself and a reader are currently testing the new formulation of Supreme and we’ll report back soon.
Related articles
The double whammy – five best products that have retinol and Matrixyl
Is Syn-tacks the new Matrixyl?
UPDATED October 2008 Five Best anti-aging serums
Calvin Klein’s foundation with matrixyl 3000
Dermapril-SP with matrixyl 3000
Relastin with matrixyl 3000 and zinc, claimed to rebuild elastin
YBF Control gets a Truth In Aging Olympics nomination
Five Best products with retinol
Reviewed and recommended: Faitox-25 with matrixyl 3000 and Argireline
Redpoint’s great wrinkle cover-up with matrixyl 3000
A new find: Glo Therapeutics with matrixyl 3000
Ingredients in Isomers Matrixyl 3000
Water/Aqua, Linum Usitatissimum (Linseed) Seed Extract, Glyceryl Polymethacrylate, Propylene Glycol, Glycerin, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Methylparaben, Propylparaben.
Ingredients in YBF Correct:
reverse osmosis water, licorice root extract, snap-8 (acetyl glutamyl hexapeptide-3), pepha-timp (polypeptide), cucumber extract, simugel (C16H34), syn-ake (tripeptide), haloxyl (hydroxysuccinimide, chrysin, palmitoyl oligopeptide (and) palmitoyl tetrapeptide-3), nutmeg butter, matrixyl 3000 (palmitoyl oligopeptide, palmitoyl tetrapeptide-3), dimethyl isosorbide, alpha arbutin, cyclomethicone (and) dimethicone copolyol, ethyhexyl palmitate, spin trap (phenyl butyl nitrone), glycerine, l-proline, provitamin B5, raspberry seed extract, alpha lipoic acid, sepilift DPHP (palmitoyl-1, palmitoyloxy-4 proline), triglyceride,
paraben du, sodium hyaluronate, caffeine, cetearyl isononanoate, ceteareth-20, cetearyl alcohol, glyceryl stearate, cetyl palmitate, ceteareth-12, vitamin e, BHT, olive leaf extract, vitamin a, violet leaf extract, oakmoss absolute
Ingredients in Bellaplex
Purified water, sesame seed oil, glycerin, silicone, Argireline (acetyl hexapeptide-3), collagen, sodium hyaluronate, matrixyl 300 (glycerin butylene glycol, water, carbomer, polysorbate 20, palmitoyl
oligopeptide, palmitoyl tetrapeptide-3), DMAE, aloe vera, alpha lipoic acid, polowax pastilles, PPG-2 myristyl ether propionate, methylparaben, propylparaben.
Ingredients in Nutra-Lift Rejuventing Therapy
Certified Organic Aloe Vera Gel, Matrixyl 3000 at 5% (Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7 PAL KTTKS), Vitamin C ester, sea kelp / algae, liposomes, astaxanthin, grape seed extract, cetyl esters, nikkomullese, co-Q10, pycogenol, natural mixed tocopherals (vitamin e), anti-oxidant complex 14, natural firming complex (dmae, alpha lipoic acid, vitamin C ester, & astaxanthin), fruit flower complex 12,
herbal complex 30, plant derived polysorbate 20, hydroxyethyl-cellulose, hyaluronic acid, copper peptide, marine collagen, marine elastine, organic royal jelly, Mexican yam, green tea, active copper peptide , milk thistle, retinyl palmitate, ( vitamin A) ppg
Ingredients in Cellbone Super AOX
Water, Shea butter, Palmitoyl Oligopeptide & Terapeptide-3 (Matrixyl™-3000), Butyleneglycol, Sunflower Seed Oil, Dimethyl Isosorbide, Cocoa Butter, Coconut Oil, Emulsifying Wax, Glycerin, Tea Tree Oil, L-Ascorbic Acid, Inca Inchi seed oil, Alpha Tocopherol, Lycopene, CoQ10,Comfrey Root Extract, Lemongrass Essential Oil, Rosemary Extract, Caprylyl Glycol, Phenoxyethanol
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Marta,
Hi, read your offer to join the TIA VIP club, but did not find any instructions on how to apply. I must have missed something, but can you clairfy the process for applying?
Be healthy, age gracefully,
Wok King
Wok King
You can click on this link to join: https://app.e2ma.net/app2/survey/26729/6944/6ad2e2b2ea/
Skin 2 Skin’s Anti-Sagging Renewal Serum is 17% Matrixyl 3000, Maximum recommended concentration, Vitamin E and cosmetic silicons (non-toxic) as the spreading agent that also sofens and hydrates the skin.
We use no water in our Anti-Sagging Renewal Serum, to diluting the the product and because we use no water that causes bacteria to grow we do not have to use any preservatives and it is unscented.
If you want a product that delivers and gets fast results Skin 2 Skin Care’s Anti-Sagging Renewal Serum is the one to use.
Matrixyl – Patmitoyl Tetrapeptide-3 – 17%
Ingredients:
Cyclopentasiloxane, Dimethicone, Dimethicone/Vinyl Dimethicone Crosspolymer, Palmitoyl Tetrapeptide-3, Tocopheryl Acetate (Vitamin E).
Oh my, this thread is quite hilarious really.
I am a biochemist and advise on skin care formulations and help individuals chose wisely. I work for no skin care company and never have.
It cracks me up that Romira/Albert used this forum to rope in people to support his/her potion when it is truly obvious that she/he knows little more than those she/he insults.
I totally agree 100% about all of the false claims and garbage products on the market and I was totally with you (Romira/Albert) until you started talking about the actual chemistry. Then I knew you were just stabbing in the dark.
There is no such thing as a 30% solution of HA. It becomes a solid at that percentage!
All of the peptide ingredients you mentioned do not do the same thing and unfortunately, you did not mention many of the good ones that compliment the Syn-COLL you chose.
It is especially distressing when anyone on this website groups “peptides” into one category.
In fact, even though it is standard industry practice now (because it sells), the peptides that act like Botox (they work on the muscles or nerves to “freeze” facial expression lines) should NEVER be smeared all over the facial skin. It is dangerous long term. When these peptides (argireline being the firt and still most well known)
My post was cut off and posted on it’s own..strange…
Anyway….
Argireline should only be applied as a spot treatment on the specific muscles that cause expression lines. The same is true for SNAP- 8 and SYN-AKE and all peptides of similar nature. These pepetides act only temporarily and have no effect on building the dermis. They have no role in the synthesis, organization or preservation of collagen. (I do consider use of more than 1-2 of these redundant.) These peptides should be in a single product category for treating expressionn lines and sold as an alternative (although obviously not as effective) as Botox injections.
Other peptides do support various stages of the collagen life cycle. If a person truly understood the chemistry of peptides, they would never post in the manner that Romira/Albert did lumping Argireline together as similar in action to Matrixyl 3000 or Syn-COLL (the last two actually being more similar!).
Later in the thread she/he seemed to retract his/her MAP, HA and Syn-COLL only formula to include other peptides she/he learned about along the way.
Some of the statements are too wild to even touch..such as comparing a certain peptide to a vectored hydroxyproline? OMG!
Just to clear up the Matrixyl 3000 argument. Sederma do NOT suggest only 3%, they suggest 3-8%, but that is only a recommendation and by no means suggests that a company testing it in their own formulation may not find improved results at 15%. While it is true that Sederma did not do trials on human skin with 15%, it is irresponsible to state that it could not be linear at higher levels. It is better to state that all we know is that it is linear to X%, but that higher additions could (or could not) prove more beneficial. Persoanlly, I would formulate at the upper end of the recommended usage level for all of my ingredients, so I would use 8% Matrixyl 3000.
http://lotioncrafter.com/pdf/matrixyl3000.pdf
I would advise staying away from anything she/he offers as it is obviously not formulated with a sound knowledge base of skin aging or peptide technology.
BTW: Anyone can buy the ingredients from Pentapharm and Sederma! They are available on many DYI skincare ingredient websites, so that is not an insider secret!
I do agree with almost everything you say about the industry in general Romira/Albert and at first thought we were long lost twins trying to expose the “truth” (expectations, price not being at all equal to value, formulations, useless long ingredient lists meant only to impress, etc.), which is why I was impresssed to stumble across a website called Truth-In-Aging!.
But after reading all of your posts, I don’t believe you worked as a formulation chemist for a cosmetics company at all. I think you are passionate about the injustice (as am I and I imagine the owners of this site are) and played around with a homebrew.
Your final creation may actually be decent, but I cannot trust your product due to your demonstrated lack of knowledge in this thread…which I realize improved as you went along researching.
I think using this site in order to market a product is in bad taste, unless there is a special area for posting your own homebrews that I have not come across yet.
HTH
Hello there,
I have read through all the comments and am more confused than ever.
I am a 46 year old lady with very deep wrinkels (when I was younger they were called laugh lines …. now they are just huge crevaces!!)
As I live in South Africa I have to usually convert the dollar price to SA Rand and the price ends up being quite hefty (the exchange rate hovers at R10.00 a dollar.
I have tried Roc products, Estee Lauder, La Mar to name a few and quite frankly do not see any difference.
Martha, you seem quite knowledgeable and I would appreciate your advice. I don’t like complicated regimes and am the kind of women that washes her faces puts on cream and then off I go.
What would you suggest I use.
Many thanks
Petalyn
This is EASY! You have a fantastic local brand called Dermaxime. I’ve been using their products recently with great results. read the review here: http://www.truthinaging.com/2009/02/reviewed-and-recommended-dermaxime-rejuvenating-toner.html
So we started out talking about Matrixyl 3000 and what is the answer/product? I have just spent hours reading and are you saying the answer is Dermaxime and does this even contain the magical Matrixyl 3000? Help!?!
Tra, I feel your pain. I’m not sure why this post encouraged such a wide range of comments. The Dermaxime recommendation was specifically for someone who is in South Africa (it’s a South African brand). Anyhow, you might want to read our recent update of Five Best with Matrixyl for the latest recommendations: http://www.truthinaging.com/2009/04/five-best-serums-with-matrixyl-3000-updated-april-2009.html
Marta,
Enjoyed Debbie (HTH) post (April 22) and tried searching for the first part of her post. Guess it’s lost?
Have a question: Several years ago, Consumers Report/Consumers Union collaborated with a sister French company to research/test various wrinkle creams that included usual drugstore brands as well as high end products including a French brand costing $335 and ounce.
The 12 week test of women between 30 and 70 years resulted in Olay Regenerist (lotion, cream, and serum-each costing $19) ranked First along with Lancome costing $88 per oz.
I checked with Olay to see if they’ve upgraded their formulation with Matrixyl 3000 and was told no, but she said they now use amino-peptides.
Question: Are you familiar with the test? Good Housekeeping also conducted a test recently and ranked Olay top rank.
The 25 ingredients for Olay’s Regenerist Serum is listed in alphabetical order for ease of viewing (do you have any comments as to which ingredients appear to be so effective as to give Olay top ranking in the two research/tests described above?):
Ingredients:
Regenerist Daily Serum – Fragrance free:
Allantoin
Benzyl Acohol
Bis-PEG/PPG-14/14 Dimethicone
Butylene Glycol
Camellia Sinensis Leaf Extract
Cetyl Ricinleate
Cyclopentasiloxane
Dimethicone
Dimethicone Crosspolymer
Disodium EDTA
Ethylparaben
Glycerin
Methylparaben
Niacinamide
Palmitoyl Pentapeptide-3
Panthenol,
Polymethylsilsesquioxane
Propylene Glycol
Propylparaben
PEG-10 Dimethicone,
PEG-100 Stearate,
PEG-10 Dimethicone/Vinyl Dimethicone Crosspolymer
Sodium Metabisulfite
Tocopheryl Acetate
Water
I do not know which ingredient(s) are considered “amino peptides.”
Be well, be safe,
Wok King
Collagen Lift is not on this list but it contains both Matrixyl 3000 and Argireline. I use it every day and its fantastic and my skin feels great.
I have seen ads for “Smooth-365″. It has Palmitoyl Oligopeptide and Acetyl Hexapeptide-8. Has anyone tried this product? If so, how did it work, and do these ingredients make up Matrixyl 3000?
I haven’t tried Smooth-365, but I can tell you that palmitoyl oligopeptide is Matrixyl, not Matrixyl 3000. It isn’t quite as potent as M3000, but still good. AH-8 is a neurpeptide that inhibits muscles from moving and creating expression lines.
I noticed on your website stating your findings regarding the top five products with Matrixyl 3000 was dated July ‘08. Do you have a more current list or does this one still stand?
I’m finding it very helpful, but of course, am concerned about getting the most up to date information.
Thank-you for your time.
Darrylin – sorry for the tardy response. We updated the top five products with matrixyl 3000 in April 2009: http://www.truthinaging.com/uncategorized/five-best-serums-with-matrixyl-3000-updated-april-2009/
Is anyone familiar with a product readily available in Canada(Vancouver)that has Matrixyl
3000 as it’s main ingredient…..(possibly containing hyluronic acid and argireline) as well???
Has anyone heard of Bellanue and Capuacu Vital?
They’re suppose to be the top of the line in anti-aging but are not listed in you picks.